1. Keithley J, Swanson B. Glucomannan and obesity: a critical review. Altern Ther Health Med . 2005;11(6):30-34. PubMed
2. Kiriyama S, Ichihara Y, Enishi A, Yoshida A. Effect of purification and cellulose treatment on the hypocholesterolemic activity of crude konjac manna. J Nutr . 1972;102(12):1689-1697. PubMed
3. Sugiyama N, Shimahara H, inventors; Kabushiki Kaisha Shimizu Manzo Shoten, assignee. Konjac mannan. US patent 3 973 008. August 3, 1976.
4. Sugiyama N, Shimahara H, inventors; Kabushiki Kaisha Shimizu Manzo Shoten, assignee. Method of reducing serum cholesterol level with extract of konjac mannan. US patent 3 856 945. December 24, 1974.
5. Chua M, Baldwin TC, Hocking TJ, Chan K. Traditional uses and potential health benefits of Amorphophallus konjac K. Koch ex N.E.Br. J Ethnopharmacol . 2010;128(2):268-278. PubMed
6. Vanderbeek PB, Fasano C, O'Malley G, Hornstein J. Esophageal obstruction from a hygroscopic pharmacobezoar containing glucomannan. Clin Toxicol (Phila) . 2007;45(1):80-82. PubMed
7. Alonso-Sande M, Teijeiro-Osorio D, Remuñán-López C, Alonso MJ. Glucomannan, a promising polysaccharide for biopharmaceutical purposes. Eur J Pharm Biopharm . 2009;72(2):453-462. PubMed
8. Chen HL, Fan YH, Chen ME, Chan Y. Unhydrolyzed and hydrolyzed konjac glucomannans modulated cecal and fecal microflora in Balb/c mice. Nutrition . 2005;21(10):1059-1064. PubMed
9. Fujiwara S, Hirota T, Nakazato H, Muzutani T, Mitsuoka T. Effect of konjac mannan on intestinal microbial metabolism in mice bearing human flora and in conventional F344 mice. Food Chem Toxicol . 1991;29(9):601-606. PubMed
10. Elamir AA, Tester RF, Al-Ghazzewi FH, et al. Effects of konjac glucomannan hydrolysates on the gut microflora of mice. Nutr Food Sci . 2008;38(5):422-429.
11. Chen HL, Cheng HC, Liu YJ, Liu SY, Wu WT. Konjac acts as a natural laxative by increasing stool bulk and improving colonic ecology in healthy adults. Nutrition . 2006;22(11-12):1112-1119. PubMed
12. Chen HL, Cheng HC, Wu WT, Liu YJ, Liu SY. Supplementation of konjac glucomannan into a low-fiber Chinese diet promoted bowel movement and improved colonic ecology in constipated adults: a placebo-controlled, diet-controlled trial. J Am Coll Nutr. 2008;27(1):102-108. PubMed
13. Loening-Baucke V, Miele E, Staiano A. Fiber (glucomannan) is beneficial in the treatment of childhood constipation. Pediatrics . 2004;113(3, pt 1):e259-e264. PubMed
14. Jenkins DJ, Wolever TM, Leeds AR, et al. Dietary fibres, fibre analogues, and glucose tolerance: importance of viscosity. Br Med J . 1978;1(6124):1392-1394. PubMed
15. Vuksan V, Sievenpiper JL, Xu Z, et al. Konjac-Mannan and American ginsing: emerging alternative therapies for type 2 diabetes mellitus. J Am Coll Nutr . 2001;20(suppl 5):370S-380S. PubMed
16. Lu XJ, Chen XM, Fu DX, Cong W, Ouyang F. Effect of Amorphophallus konjac oligosaccharides on STZ-induced diabetes model of isolated islets. Life Sci . 2002;72(6):711-719. PubMed
17. Guar gum, dietary fiber and diabetes. Med Lett Drugs Ther . 1979;21(12):51-52. PubMed
18. Doi K, Matsuura M, Kawara A, Baba S. Treatment of diabetes with glucomannan (konjac mannan). Lancet . 1979;1(8123):987-988. PubMed
19. Huang CY, Zhang MY, Peng SS, et al. Effect of Konjac food on blood glucose level in patients with diabetes. Biomed Environ Sci . 1990;3(2):123-131. PubMed
20. Chearskul S, Kriengsinyos W, Kooptiwut S, et al. Immediate and long-term effects of glucomannan on total ghrelin and leptin in type 2 diabetes mellitus. Diabetes Res Clin Pract . 2009;83(2):e40-e42. PubMed
21. Sood N, Baker WL, Coleman CI. Effect of glucomannan on plasma lipid and glucose concentrations, body weight, and blood pressure: systematic review and meta-analysis. Am J Clin Nutr . 2008;88(4):1167-1175. PubMed
22. Reffo GC, Ghirardi PE, Forattini C. Double-blind evaluation of glucomannan versus placebo in postinfarcted patients after cardiac rehabilitation. Curr Ther Res Clin Exp . 1990;47(5):753-758.
23. Kraemer WJ, Vingren JL, Silvestre R, et al. Effect of adding exercise to a diet containing glucomannan. Metabolism . 2007;56(8):1149-1158. PubMed
24. Vido L, Facchin P, Antonello I, Gobber D, Rigon F. Childhood obesity treatment: double blinded trial on dietary fibres (glucomannan) versus placebo. Padiatr Padol . 1993;28(5):133-136. PubMed
25. Rogovik AL, Chanoine JP, Goldman RD. Pharmacotherapy and weight-loss supplements for treatment of paediatric obesity. Drugs . 2010;70(3):335-346. PubMed
26. Livieri C, Novazi F, Lorini R. The use of highly purified glucomannan-based fibers in childhood obesity [in Italian]. Pediatr Med Chir . 1992;14(2):195-198. PubMed
27. Lyon MR, Reichert RG. The effect of a novel viscous polysaccharide along with lifestyle changes on short-term weight loss and associated risk factors in overweight and obese adults: an observational retrospective clinical program analysis. Altern Med Rev . 2010;15(1):68-75. PubMed
28. Kiriyama S, Enishi A, Yura K. Inhibitory effect of konjac mannan on bile acid transport in the everted sacs from rat ileum. J Nutr . 1974;104(1):69-78. PubMed
29. McCarty MF. Glucomannan minimizes the postprandial insulin surge: a potential adjuvant for hepatothermic therapy. Med Hypotheses . 2002;58(6):487-490. PubMed
30. Kiriyama S, Okazaki Y, Yoshida A. Hypocholesterolemic effect of polysaccharides and polysaccharide-rich foodstuffs in cholesterol-fed rats. J Nutr . 1969;97(3):382-388. PubMed
31. Ikegami S, Harada H, Tshuchihashi N, Nagayama S, Nishide E, Innami S. Effect of indigestible polysaccharides on pancreatic exocrine secretion and biliary output. J Nutr Sci Vitaminol (Tokyo) . 1984;30(6):515-523. PubMed
32. Arvill A, Bodin L. Effect of short-term ingestion of konjac glucomannan on serum cholesterol in healthy men. Am J Clin Nutr . 1995;61(3):585-589. PubMed
33. Zhang MY, Huang CY, Wang X, Hong JR, Peng SS. The effect of foods containing refined Konjac meal on human lipid metabolism. Biomed Environ Sci . 1990;3(1):99-105. PubMed
34. Hou YH, Zhang LS, Zhou HM, Wang RS, Zhang YZ. Influences of refined konjac meal on the levels of tissue lipids and the absorption of four minerals in rats. Biomed Environ Sci . 1990;3(3):306-314. PubMed
35. Shimizu H, Yamauchi M, Kuramoto T, Kubota N, Matsuda M, Hoshita T. Effects of dietary konjac mannan on serum and liver cholesterol levels and biliary bile acid composition in hamsters. J Pharmacobiodyn . 1991;14(7):371-375. PubMed
36. Wood RJ, Fernandez ML, Sharman MJ, et al. Effects of a carbohydrate-restricted diet with and without supplemental soluble fiber on plasma low-density lipoprotein cholesterol and other clinical markers of cardiovascular risk. Metabolism . 2007;56(1):58-67. PubMed
37. Martino F, Martino E, Morrone F, Carnevali E, Forcone R, Niglio T. Effect of dietary supplementation with glucomannan on plasma total cholesterol and low density lipoprotein cholesterol in hypercholesterolemic children. Nutr Metab Cardiovasc Dis . 2005;15(3):174-180. PubMed
38. Luo DY. Inhibitory effect of refined Amorphophallus konjac on MNNG-induced lung cancers in mice [in Chinese]. Zhonghua Zhong Liu Za Zhi . 1992;14(1):48-50. PubMed
39. Onishi N, Kawamoto S, Suzuki H, et al. Dietary pulverized konjac glucomannan suppresses scratching behavior and skin inflammatory immune responses in NC/Nga mice. Int Arch Allergy Immunol . 2007;144(2):95-104. PubMed
40. Onishi N, Kawamoto S, Suzuki H, Hide M, Ono K. Development of autoantibody responses in NC/Nga mice: its prevention by pulverized konjac glucomannan feeding. Arch Dermatol Res . 2008;300(2):95-99. PubMed
41. Azezli AD, Bayraktaroglu T, Orhan Y. The use of konjac glucomannan to lower serum thyroid hormones in hyperthyroidism. J Am Coll Nutr . 2007;26(6):663-668. PubMed
42. Onishi N, Kawamoto S, Ueda K, et al. Dietary pulverized konjac glucomannan prevents the development of allergic rhinitis-like symptoms and IgE response in mice. Biosci Biotechnol Biochem . 2007;71(10):2551-2556. PubMed
43. Li S, Hu T, Chen Y, et al. Chemically modified konjac glucomannan with high colloid osmotic pressure: physiological evaluation in a rabbit model as a plasma substitute. Glycobiology . 2010;20(8):950-958. PubMed
44. Al-Ghazzewi FH, Tester RF. Effect of konjac glucomannan hydrolysates and probiotics on the growth of the skin bacterium Propionibacterium acnes in vitro. Int J Cosmet Sci . 2010:32(2):139-142. PubMed
45. Alvarez-Manceñido F, Landin M, Martínez-Pacheco R. Konjac glucomannan/xanthan gum enzyme sensitive binary mixtures for colonic drug delivery. Eur J Pharm Biopharm . 2008;69(2):573-581. PubMed
46. Chen HL, Sheu WH, Tai TS, Liaw YP, Chen YC. Konjac supplement alleviated hypercholesterolemia and hyperglycemia in type 2 diabetic subjects—a randomized double-blind trial. J Am Coll Nutr . 2003;22(1):36-42. PubMed
47. Vuksan V, Sievenpiper JL, Owen R, et al. Beneficial effects of viscous dietary fiber from Konjac-mannan in subjects with the insulin resistance syndrome: results of a controlled metabolic trial. Diabetes Care . 2000;23(1):9-14. PubMed
48. Marsicano LJ, Berrizbeitia ML, Mondelo A. Use of glucomannan dietary fiber in changes in intestinal habit [in Spanish]. G E N . 1995;49(1):7-14. PubMed
49. Walsh DE, Yaghoubian V, Behforooz A. Effect of glucomannan on obese patients: a clinical study. Int J Obes . 1984;8(4):289-293. PubMed
50. Fung M. Glucomanna diet tablets. Med J Aust . 1984;140(6):350. PubMed
51. Gaudry P. Glucomanna diet tablets. Med J Aust . 1985;142(3):204. PubMed
52. Henry DA, Mitchell AS, Aylward J, Fung MT, McEwen J, Rohan A. Glucomannan and risk of oesophageal obstruction. Br Med J (Clin Res Ed) . 1986;292(6520):591-92. PubMed
53. Villaverde AF, Benlloch S, Berenguer M, Rayón JM, Pina R, Berenguer J. Acute hepatitis of cholestatic type possibly associated with the use of glucomannan ( Amorphophalus konjac ). J Hepatol . 2004;41(6):1061-1062. PubMed
54. Bernstein JA, Crandall MS, Floyd R. Respiratory sensitization of a food manufacturing worker to konjac glucomannan. J Asthma . 2007;44(8):675-680. PubMed
55. Peng SS, Zhang MY, Zhang YZ, Wu ZH. Long-term animal feeding trial of the refined konjac meal. II. Effects of the refined konjac meal on the aging of the brain, liver, and cardiovascular tissue cells in rats. Biomed Environ Sci . 1995;8(1):80-87. PubMed