1. Hibiscus sabdariffa L. USDA, NRCS. 2009. The PLANTS Database ( http://plants.usda.gov , January 2009). National Plant Data Center, Baton Rouge, LA 70874-4490 USA.
2. Ali BH, Al Wabel N, Blunden G. Phytochemical, pharmacological and toxicological aspects of Hibiscus sabdariffa L.: a review. Phytother Res . 2005;19(5):369-375. PubMed
3. Leung AY. Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics . New York, NY: J Wiley; 1980.
4. Haruna AK. Cathartic activity of soborodo : the aqueous extract of calyx of Hibiscus sabdariffa L. Phytother Res . 1997;11:307-308.
5. Abu-Tarboush HM, Ahmed SA, Al Kahtani HA. Some nutritional and functional properties of karkade ( Hibiscus sabdariffa ) seed products. Cereal Chem . 1997;74(3):352-355.
6. Haji Faraji M, Haji Tarkhani AH. The effect of sour tea ( Hibiscus sabdariffa ) on essential hypertension. J Ethnopharmacol . 1999;65(3):231-236. PubMed
7. Du CT, Francis FJ. Anthocyanins of roselle ( Hibiscus sabdariffa ). J Food Sci . 1973;38:810-812.
8. Wilkinson M, Sweeney JG, Lacobucci GA. High performance liquid chromatography of anthocyanins. J Chromatogr . 1977;132:349-351.
9. Sayago-Ayerdi SG, Arranz S, Serrano J, Goni I. Dietary fiber content and associated antioxidant compounds in Roselle flower ( Hibiscus sabdariffa L.) beverage. J Agric Food Chem . 2007;55(19):7886-7890. PubMed
10. Mohamed R, Fernandez J, Pineda M, Aguilar M. Roselle ( Hibiscus sabdariffa ) seed oil is a rich source of gamma-tocopherol. J Food Sci . 2007;72(3):S207-S211. PubMed
11. Tseng TH, Hsu JD, Lo MH, et al. Inhibitory effect of Hibiscus protocatechuic acid on tumor promotion in mouse skin. Cancer Lett . 1998;126(2):199-207. PubMed
12. Tseng TH, Kao TW, Chu CY, Chou FP, Lin WL, Wang CJ. Induction of apoptosis by Hibiscus protocatechuic acid in human leukemia cells via reduction of retinoblastoma (RB) phosphorylation and Bcl-2 expression. Biochem Pharmacol . 2000;60(3):307-315. PubMed
13. Chang YC, Huang HP, Hsu JD, Yang SF, Wang CJ. Hibiscus anthocyanins rich extract-induced apoptotic cell death in human promyelocytic leukemia cells. Toxicol Appl Pharmacol . 2005;205(3):201-212. PubMed
14. Hou DX, Tong X, Terahara N, Luo D, Fujii M. Delphinidin 3-sambubioside, a Hibiscus anthocyanin, induces apoptosis in human leukemia cells through reactive oxygen species-mediated mitochondrial pathway. Arch Biochem Biophys . 2005;440(1):101-109. PubMed
15. Lin HH, Chen JH, Kuo WH, Wang CJ. Chemopreventive properties of Hibiscus sabdariffa L. on human gastric carcinoma cells through apoptosis induction and JNK/p38 MAPK signaling activation. Chem Biol Interact . 2007;165(1):59-75. PubMed
16. Lo CW, Huang HP, Lin HM, Chien CT, Wang CJ. Effect of Hibiscus anthocyanins-rich extract induces apoptosis of proliferating smooth muscle cell via activation of P38 MAPK and p53 pathway. Mol Nutr Food Res . 2007;51(12):1452-1460. PubMed
17. Olvera-García V, Castaño-Tostado E, Rezendiz-Lopez RI, et al. Hibiscus sabdariffa L. extracts inhibit the mutagenicity in microsuspension assay and the proliferation of HeLa cells. J Food Sci . 2008;73(5):75-81. PubMed
18. Hirunpanich V, Utaipat A, Morales NP, et al. Antioxidant effects of aqueous extracts from dried calyx of Hibiscus sabdariffa Linn. (Roselle) in vitro using rat low-density lipoprotein (LDL). Biol Pharm Bull . 2005;28(3):481-484. PubMed
19. Hirunpanich V, Utaipat A, Morales NP, et al. Hypocholesterolemic and antioxidant effects of aqueous extracts from the dried calyx of Hibiscus sabdariffa L. in hypercholesterolemic rats. J Ethnopharmacol . 2006;103(2):252-260. PubMed
20. Chang YC, Huang KX, Huang AC, Ho YC, Wang CJ. Hibiscus anthocyanins-rich extract inhibited LDL oxidation and oxLDL-mediated macrophages apoptosis. Food Chem Toxicol . 2006;44(7):1015-1023.
21. Carvajal-Zarrabal O, Waliszewski SM, Barradas-Dermitz DM, et al. The consumption of Hibiscus sabdariffa dried calyx ethanolic extract reduced lipid profile in rats. Plant Foods Hum Nutr . 2005;60(4):153-159. PubMed
22. Alarcon-Aguilar FJ, Zamilpa A, Perez-Garcia MD, et al. Effect of Hibiscus sabdariffa on obesity in MSG mice. J Ethnopharmacol . 2007;114(1):66-71. PubMed
23. Chen CC, Hsu JD, Wang SF, et al. Hibiscus sabdariffa extract inhibits the development of atherosclerosis in cholesterol-fed rabbits. J Agric Food Chem . 2003;51(18):5472-5477. PubMed
24. Farombi EO, Ige OO. Hypolipidemic and antioxidant effects of ethanolic extract from dried calyx of Hibiscus sabdariffa in alloxan-induced diabetic rats. Fundam Clin Pharmacol . 2007;21(6):601-609. PubMed
25. Odigie IP, Ettarh RR, Adigun SA. Chronic administration of aqueous extract of Hibiscus sabdariffa attenuates hypertension and reverses cardiac hypertrophy in 2K-1C hypertensive rats. J Ethnopharmacol . 2003;86(2-3):181-185. PubMed
26. Ajay M, Chai HJ, Mustafa AM, Gilani AH, Mustafa MR. Mechanisms of the anti-hypertensive effect of Hibiscus sabdariffa L. calyces. J Ethnopharmacol . 2007;109(3):388-393. PubMed
27. Mojiminiyi FB, Dikko M, Muhammad BY, et al. Antihypertensive effect of an aqueous extract of the calyx of Hibiscus sabdariffa . Fitoterapia . 2007;78(4):292-297. PubMed
28. Herrera-Arellano A, Flores-Romero S, Chavez-Soto MA, Tortoriello J. Effectiveness and tolerability of a standardized extract from Hibiscus sabdariffa in patients with mild to moderate hypertension: a controlled and randomized clinical trial. Phytomedicine . 2004;11(5):375-382. PubMed
29. Herrera-Arellano A, Miranda-Sánchez J, Avila-Castro P, et al. Clinical effects produced by a standardized herbal medicinal product of Hibiscus sabdariffa on patients with hypertension. A randomized, double-blind, lisinopril-controlled clinical trial. Planta Med . 2007;73(1):6-12. PubMed
30. Kirdpon S, Nakorn SN, Kirdpon W. Changes in urinary chemical composition in healthy volunteers after consuming roselle ( Hibiscus sabdariffa Linn.) juice. J Med Assoc Thai . 1994;77(6):314-321. PubMed
31. Prasongwatana V, Woottisin S, Sriboonlue P, Kukongviriyapan V. Uricosuric effect of Roselle ( Hibiscus sabdariffa ) in normal and renal-stone former subjects. J Ethnopharmacol . 2008;117(3):491-495. PubMed
32. Fouda AM, Daba MH, Dahab GM. Inhibitory effects of aqueous extract of Hibiscus sabdariffa on contractility of the rat bladder and uterus. Can J Physiol Pharmacol . 2007;85(10):1020-1031. PubMed
33. Hansawasdi C, Kawabata J, Kasai T. α-Amylase inhibitors from roselle ( Hibiscus sabdariffa Linn.) tea. Biosci Biotechnol Biochem . 2000;64(5):1041-1043. PubMed
34. Wang CJ, Wang JM, Lin WL, Chu CY, Chou FP, Tseng TH. Protective effect of Hibiscus anthocyanins against tert -butyl hydroperoxide-induced hepatic toxicity in rats. Food Chem Toxicol . 2000;38(5):411-416. PubMed
35. Amin A, Hamza AA. Effects of Roselle and Ginger on cisplatin-induced reproductive toxicity in rats. Asian J Androl . 2006;8(5):607-612. PubMed
36. Liu JY, Chen CC, Wang WH, Hsu JD, Yang MY, Wang CJ. The protective effects of Hibiscus sabdariffa extract on CCl4-induced liver fibrosis in rats. Food Chem Toxicol . 2006;44(3):336-343. PubMed
37. Frank T, Janssen M, Netzel M, et al. Pharmacokinetics of anthocyanidin-3-glycosides following consumption of Hibiscus sabdariffa L. extract. J Clin Pharmacol . 2005;45(2):203-210. PubMed
38. Ernst E. Herbal medicinal products during pregnancy: are they safe? BJOG . 2002;109(3):227-235. PubMed
39. Mahmoud BM, Ali HM, Homeida MM, Bennett JL. Significant reduction in chloroquine bioavailability following coadministration with Sudanese beverages Aradaib, Karkadi, and Lemon. J Antimicrob Chemother . 1994;33(5):1005-1009. PubMed
40. Fakeye TO, Adegoke AO, Omoyeni OC, Famakinde AA. Effects of water extract of Hibiscus sabdariffa , Linn (Malvaceae) 'Roselle' on excretion of a diclofenac formulation. Phytother Res . 2007;21(1):96-98. PubMed
41. Amin A, Hamza AA. Hepatoprotective effects of Hibiscus, Rosmarinus and Salvia on azathioprine-induced toxicity in rats. Life Sci . 2005;77(3):266-278. PubMed