1. Sumi H, Hamada H, Tsushima H, Mihara H, Muraki H. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto ; a typical and popular soybean food in the Japanese diet. Experientia . 1987;43(10):1110-1111. PubMed
2. Tai MW, Sweet BV. Nattokinase for prevention of thrombosis. Am J Health Syst Pharm . 2006;63(12):1121-1123. PubMed
3. Ku TW, Tsai RL, Pan TM. A simple and cost-saving approach to optimize the production of subtilisin NAT by submerged cultivation of Bacillus subtilis natto . J Agric Food Chem . 2009;57(1):292-296. PubMed
4. Wang C, Du M, Zheng D, et al. Purification and Characterization of nattokinase from Bacillus subtilis Natto B-12. [published online ahead of print Sep 29, 2009]. J Agric FoodChem . doi:10.1021/jf901861v. PubMed
5. Sugimoto S, Fujii T, Morimiya T, Johdo O, Nakamura T. The fibrinolytic activity of a novel protease derived from a tempeh producing fungus, Fusarium sp.BLB. Biosci Biotechnol Biochem . 2007;71(9):2184-2189. PubMed
6. Inatsu Y, Nakamura N, Yuriko Y, Fushimi T, Watanasiritum L, Kawamoto S. Characterization of Bacillus subtilis strains in Thua nao, a traditional fermented soybean food in northern Thailand. Lett Appl Microbiol . 2006;43(3):237-242. PubMed
7. Fujita M, Nomura K, Hong K, Ito Y, Asada A, Nishimuro S. Purification and characterization of a strong fibrinolytic enzyme (nattokinase) in the vegetable cheese natto, a popular soybean fermented food in Japan. Biochem Biophys Res Commun . 1993;197(3):1340-1347. PubMed
8. Weng M, Zheng Z, Bao W, Cai Y, Yin Y, Zou G. Enhancement of oxidative stability of the subtilisin nattokinase by site-directed mutagenesis expressed in Escherichia coli . Biochim Biophys Acta . 2009;1794(11):1566-1572. PubMed
9. Peng Y, Yang X, Zhang Y. Microbial fibrinolytic enzymes: an overview of source, production, properties, and thrombolytic activity in vivo. Appl Microbiol Biotechnol . 2005;69(2):126-132. PubMed
10. Hsu RL, Lee KT, Wang JH, Lee LY, Chen RP. Amyloid-degrading ability of nattokinase from Bacillus subtilis natto. J Agric Food Chem . 2009;57(2):503-508. PubMed
11. Pais E, Alexy T, Holsworth RE Jr, Meiselman HJ. Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity. Clin Hemorheol Microcirc . 2006;35(1-2):139-142. PubMed
12. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci . 2003;73(10):1289-1298. PubMed
13. Suzuki Y, Kondo K, Ichise H, Tsukamoto Y, Urano T, Umemura K. Dietary supplementation with fermented soybeans suppresses intimal thickening. Nutrition . 2003;19(3):261-264. PubMed
14. Fujita M, Hong K, Ito Y, Fujii R, Kariya K, Nishimuro S. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biol Pharm Bull . 1995;18(10):1387-1391. PubMed
15. Lee T. Ask the doctor. I would like to find a safer, easier alternative to warfarin, which I have been taking for a couple of years. I have been hearing about nattokinase—can I take it in place of warfarin? Harv Heart Lett . 2006;17(2):7. PubMed
16. Hsia CH, Shen MC, Lin JS, et al. Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Nutr Res . 2009;29(3):190-196. PubMed
17. Cesarone MR, Belcaro G, Nicolaides AN, et al. Prevention of venous thrombosis in long-haul flights with Flite Tabs : the LONFLIT-FLITE randomized, controlled trial. Angiology . 2003;54(5):531-539. PubMed
18. Yang NC, Chou CW, Chen CY, Hwang KL, Yang YC. Combined nattokinase with red yeast rice but not nattokinase alone has potent effects on blood lipids in human subjects with hyperlipidemia. Asia Pac J Clin Nutr . 2009;18(3):310-317. PubMed
19. Kim JY, Gum SN, Paik JK, et al. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens Res . 2008;31(8):1583-1588. PubMed
20. Takano A, Hirata A, Ogasawara K, et al. Posterior vitreous detachment induced by nattokinase (subtilisin NAT): a novel enzyme for pharmacologic vitreolysis. Invest Ophthalmol Vis Sci. 2006;47(5):2075-2079. PubMed
21. Chang YY, Liu JS, Lai SL, Wu HS, Lan MY. Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Intern Med . 2008;47(5):467-469. PubMed